Retroperitoneoscopy has gained popularity because it offers a safe alternative to the more debilitating open approach and avoids postoperative ileus. However, this type of procedure carries certain disadvantages in terms of intraperitoneal effusions and hemodynamic changes. Major complications are exceptional. We describe the case of a 52-year-old man who died of carbon dioxide embolism during elective totally extraperitoneal (TEP) inguinal hernioplasty for symptomatic left indirect inguinal hernia. With the patient under general anesthesia, the retroperitoneal space was gained through a 1. 5-cm incision made below the umbilicus. During the dissection, the patient collapsed and could not be resuscitated. At autopsy, air bubbles were admixed with blood in the epicardial veins, but no injury to vessels was demonstrated. We conclude that carbon dioxide embolism usually is caused by direct puncture of major vessels during intra-abdominal procedures. However, when this complication occurs during retroperitoneoscopy, it seems related to pressure-forced entry of carbon dioxide into the venous plexus.