Detection of P2X purinergic receptors on human B lymphocytes
Copyright policy )Detection of P2X purinergic receptors on human B lymphocytes
B lymphocytes are known to synthesise the P2X7 subtype of the P2X purinergic receptor family; however, the identification of the other six P2X subtypes on these cells has been limited by the absence of specific antibodies. In this study, we used a panel of anti-P2X polyclonal antibodies and confocal microscopy to examine the presence of each P2X receptor on human B lymphocytes. We observed that P2X1, P2X2, P2X4 and P2X7 subtypes, but not P2X3, P2X5 and P2X6 subtypes, are present on B lymphocytes.
- University of Sydney Australia
- University of Wollongong Australia
- Nepean Hospital Australia
lymphocytes, detection, receptors, Cross Reactions, Social and Behavioral Sciences, Antibodies, Epitopes, Structure-Activity Relationship, Adenosine Triphosphate, Physical Sciences and Mathematics, Humans, purinergic, human, B-Lymphocytes, Microscopy, Confocal, Receptors, Purinergic P2, Receptors, Purinergic, p2x, Life Sciences, Immunohistochemistry, Leukemia, Lymphocytic, Chronic, B-Cell, Receptors, Purinergic P2X, b, CMMB, Ion Channel Gating
lymphocytes, detection, receptors, Cross Reactions, Social and Behavioral Sciences, Antibodies, Epitopes, Structure-Activity Relationship, Adenosine Triphosphate, Physical Sciences and Mathematics, Humans, purinergic, human, B-Lymphocytes, Microscopy, Confocal, Receptors, Purinergic P2, Receptors, Purinergic, p2x, Life Sciences, Immunohistochemistry, Leukemia, Lymphocytic, Chronic, B-Cell, Receptors, Purinergic P2X, b, CMMB, Ion Channel Gating
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