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The complement system

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 14 Sep 2010 English Publisher:Springer Science and Business Media LLCJournal:Cell and Tissue Research, volume 343, pages 227-235 (issn: 0302-766X, eissn: 1432-0878,

Authors: Peter A. Ward; J. Vidya Sarma;

doi: 10.1007/s00441-010-1034-0

pmid: 20838815

pmc: PMC3097465

The complement system

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Abstract

The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis. Inappropriate complement activation and complement deficiencies are the underlying cause of the pathophysiology of many diseases such as systemic lupus erythematosus and asthma. This review represents an overview of the complement system in an effort to understand the beneficial as well as harmful roles it plays during inflammatory responses.

Related Organizations

University of Michigan–Flint
United States

Keywords

Anaphylatoxins, Animals, Humans, Review, Complement System Proteins, Adaptive Immunity, Complement Activation, Immune Evasion

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	806
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 0.1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 0.1%