Sequence variation of a variable short tandem repeat at the D18S535 locus

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1998Publisher:Springer Science and Business Media LLCJournal:International Journal of Legal Medicine, volume 111, pages 337-339 (issn: 0937-9827, eissn: 1437-1596,

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Authors: M V, Lareu; S, Barral; A, Salas; A, Carracedo;

doi: 10.1007/s004140050185

pmid: 9826098

Sequence variation of a variable short tandem repeat at the D18S535 locus

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Abstract

A short tandem repeat in the D18S535 locus was sequenced in 25 selected alleles. A total of 8 different alleles were found which can be designated according to the total number of repeats. This STR is a simple hypervariable STR consisting of blocks of (GATA) repeats with a basic sequence structure (GATA)1(GACA)1(GATA)1 (GAT)1(GATA)9-16. Population data showed that this is a highly polymorphic STR with a heterozygosity of more than 0.80, a simple structure and small size (130-158 bp) which makes this an interesting DNA polymorphism for forensic and genetic purposes.

Related Organizations

American Board of Legal Medicine
United States

Keywords

Polymorphism, Genetic, Gene Frequency, Spain, Tandem Repeat Sequences, Terminology as Topic, Humans, DNA

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