Transcriptional regulation of matrix gla protein

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2001Publisher:Springer Science and Business Media LLCJournal:Zeitschrift f�r Kardiologie, volume 90, pages III38-III42 (issn: 0300-5860, eissn: 1435-1285,

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Authors: A, Farzaneh-Far; P L, Weissberg; D, Proudfoot; C M, Shanahan;

doi: 10.1007/s003920170040

pmid: 11374031

Transcriptional regulation of matrix gla protein

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Abstract

Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.

Related Organizations

University of Cambridge
United Kingdom
Cambridge University Hospitals NHS Foundation Trust
United Kingdom
Addenbrooke's Hospital
United Kingdom

Keywords

Extracellular Matrix Proteins, Matrix Gla Protein, Transcription, Genetic, Arteriosclerosis, Calcium-Binding Proteins, Calcinosis, Down-Regulation, Tretinoin, Muscle, Smooth, Vascular, Rats, Up-Regulation, Gene Expression Regulation, Transforming Growth Factor beta, Cyclic AMP, Animals, Humans, Cholecalciferol

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