Radioimmunotherapy of B-cell non-Hodgkin's lymphoma

descriptionPublicationkeyboard_double_arrow_right Article 02 Jun 2001 Netherlands English Publisher:Springer Science and Business Media LLCJournal:European Journal of Nuclear Medicine, volume 28, pages 1,725-1,735 (issn: 0340-6997, eissn: 1619-7089,

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Authors: Postema, E.J.; Boerman, O.C.; Oyen, W.J.G.; Raemaekers, J.M.M.; Corstens, F.H.M.;

doi: 10.1007/s002590100570

pmid: 11702116

handle: 2066/267033

Radioimmunotherapy of B-cell non-Hodgkin's lymphoma

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Abstract

In the past decade, several new antibody-based therapies - using either radiolabelled or unlabelled monoclonal antibodies - have become available for the treatment of patients with refractory or recurrent non-Hodgkin's lymphoma (NHL). Unlabelled monoclonal antibodies (mAbs) kill lymphoma cells by activating host immune effector mechanisms, or by inducing apoptosis. These mAbs can also be used to guide radionuclides to the lymphoma. This radioimmunotherapy (RIT) has been studied with various nuclides (131I, 90Y, 67Cu and 186Re) and with various mAbs. In this review the radionuclides, methods of dosing and recent RIT studies in patients with B-cell NHL are reviewed. Most of these studies demonstrate that RIT is an effective new treatment modality for NHL.

Country

Netherlands

Related Organizations

University Medical Center
United States
Radboud University Nijmegen Medical Centre
Netherlands
Radboud University Nijmegen
Netherlands

Keywords

Radioisotopes, Lymphoma, B-Cell, Development of radiopharmaceuticals for diagnosis and therapy of pathological processes., Antibodies, Monoclonal, Humans, Radioimmunotherapy, Ontwikkeling van radiofarmaca ten behoeve van diagnose en behandeling van ziekteprocessen.

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