Serial imaging in MELAS
Copyright policy )Serial imaging in MELAS
We report two patients with fatal mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Single-photon emission computed tomography (SPECT) with 123I-N-isopropyl-p-iodoamphetamine was more sensitive to the lesions than CT or MRI. SPECT showed focal hyperperfusion before or during the stroke and diffuse hypoperfusion of the brain, sparing the basal ganglia in the terminal stages. These findings support the theory that metabolic disturbance in the brain causes the "stroke" in MELAS.
Tomography, Emission-Computed, Single-Photon, Amphetamines, Brain, Iofetamine, Magnetic Resonance Imaging, Sensitivity and Specificity, Iodine Radioisotopes, Fatal Outcome, Regional Blood Flow, MELAS Syndrome, Humans, Female, Child, Energy Metabolism, Tomography, X-Ray Computed
Tomography, Emission-Computed, Single-Photon, Amphetamines, Brain, Iofetamine, Magnetic Resonance Imaging, Sensitivity and Specificity, Iodine Radioisotopes, Fatal Outcome, Regional Blood Flow, MELAS Syndrome, Humans, Female, Child, Energy Metabolism, Tomography, X-Ray Computed
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