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Effect of omeprazole on the pharmacokinetics of itraconazole

descriptionPublicationkeyboard_double_arrow_right Article 30 Apr 1998Publisher:Springer Science and Business Media LLCJournal:European Journal of Clinical Pharmacology, volume 54, pages 159-161 (issn: 0031-6970, eissn: 1432-1041,

Authors: Somchai Sriwiriyajan; Sutep Jaruratanasirikul;

doi: 10.1007/s002280050438

pmid: 9626921

Effect of omeprazole on the pharmacokinetics of itraconazole

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Abstract

To investigate the effect of omeprazole on the pharmacokinetics of itraconazole.Eleven healthy volunteers received a single dose of oral itraconazole (200 mg) on days 1 and 15 and oral omeprazole (40 mg) once daily from day 2 to day 15. Itraconazole pharmacokinetics were studied on days 1 and 15.Concentrations of itraconazole were higher when it was taken alone than when it was taken with omeprazole. With concomitant omeprazole treatment, the mean AUC0-24 and Cmax of itraconazole were significantly reduced by 64% and 66%, respectively.Omeprazole affects itraconazole kinetics, leading to a reduction in bioavailability and Cmax. These two drugs should not be used together.

Related Organizations

Prince of Songkla University
Thailand

Keywords

Adult, Male, Antifungal Agents, Biological Availability, Anti-Ulcer Agents, Reference Values, Humans, Drug Interactions, Female, Itraconazole, Omeprazole

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	130
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%