Inhibition of Matrix Metalloproteinase-1 by Dichloromethylene Bisphosphonate (Clodronate)
Copyright policy )Inhibition of Matrix Metalloproteinase-1 by Dichloromethylene Bisphosphonate (Clodronate)
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.
- University of Helsinki Finland
- Oulu University Hospital Finland
- University of Oulu Finland
Dose-Response Relationship, Drug, Jaw Cysts, Fibroblasts, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinase 8, Humans, Collagen, Collagenases, Bone Diseases, Clodronic Acid, Matrix Metalloproteinase 1
Dose-Response Relationship, Drug, Jaw Cysts, Fibroblasts, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinase 8, Humans, Collagen, Collagenases, Bone Diseases, Clodronic Acid, Matrix Metalloproteinase 1
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