The most metal-poor stars found in the Galaxy and in nearby galaxies are witnesses of the early evolution of the Universe. In a general picture in which we expect the metallicity to increase monotonically with time, as a result of the metal production in stars, we also expect the most metal-poor stars to be the most primitive objects accessible to our observations. The abundance ratios in these stars provide us important information on the first generations of stars that synthesised the nuclei that we observe in these stars. Because they are so primitive the modelling of their chemical inventory can be often satisfactorily achieved by assuming that all the metals were produced in a single supernova, or just a few. This is simpler than modelling the full chemical evolution, using different sources, that is necessary at higher metallicity. The price to pay for this relative ease of interpretation is that these stars are extremely rare and require specifically tailored observational strategies in order to assemble statistically significant samples of stars. In this review we try to summarise the main observational results that have been obtained in the last ten years.

Accepted for publication on The Astronomy & Astrophysics Review, typos corrected, one reference was missing from the latex source in the previous version