Bacterial Cytotoxins Target Rho GTPases

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1998 Germany English Publisher:Springer Science and Business Media LLCJournal:Naturwissenschaften, volume 85, pages 253-261 (issn: 0028-1042, eissn: 1432-1904,

Copyright policy )

Authors: Schmidt, Gudula; Aktories, Klaus;

doi: 10.1007/s001140050495

pmid: 9686394

Bacterial Cytotoxins Target Rho GTPases

- Summary
- Subjects
- Metrics

Abstract

Low molecular mass GTPases of the Rho family, which are involved in the regulation of the actin cytoskeleton and in various signal transduction processes, are the eukaryotic targets of bacterial protein toxins. The toxins covalently modify Rho proteins by ADP ribosylation, glucosylation, and deamidation, thereby inactivating and activating the GTPases.

Country

Germany

Related Organizations

University of Freiburg
Germany
Institut für Pharmakologie und Toxikologie der Bundeswehr
Germany

Keywords

Clostridium, Mammals, Transglutaminases, Cytotoxins, Bacterial Toxins, GTPase-Activating Proteins, Proteins, GTP Phosphohydrolases, GTP-Binding Proteins, ras GTPase-Activating Proteins, ras Proteins, Animals, Poly(ADP-ribose) Polymerases, Cytoskeleton, Signal Transduction

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	20
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%