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The cellular functions of clathrin

Name: The cellular functions of clathrin
Creator: Stephen J. Royle
Keywords: Dynamins, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Protein Conformation, Cell Membrane, Animals, Humans, Mitosis, Clathrin-Coated Vesicles

descriptionPublicationkeyboard_double_arrow_right Article 15 May 2006Publisher:Springer Science and Business Media LLCJournal:Cellular and Molecular Life Sciences, volume 63, pages 1,823-1,832 (issn: 1420-682X, eissn: 1420-9071,

Authors: Stephen J. Royle;

doi: 10.1007/s00018-005-5587-0

pmid: 16699812

pmc: PMC3475309

The cellular functions of clathrin

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Abstract

Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a new function for clathrin that occurs during mitosis.

Related Organizations

Medical Research Council
United Kingdom
MRC Laboratory of Molecular Biology
United Kingdom

Keywords

Dynamins, Protein Conformation, Cell Membrane, Animals, Humans, Mitosis, Clathrin-Coated Vesicles, Clathrin, Endocytosis

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	125
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