
doi: 10.1007/pl00000072
pmid: 11271508
An ancestral influence graph is derived, an analogue of the coalescent and a composite of Griffiths' (1991) two-locus ancestral graph and Krone and Neuhauser's (1997) ancestral selection graph. This generalizes their use of branching-coalescing random graphs so as to incorporate both selection and recombination into gene genealogies. Qualitative understanding of a 'hitch-hiking' effect on genealogies is pursued via diagrammatic representation of the genealogical process in a two-locus, two-allele haploid model. Extending the simulation technique of Griffiths and Tavare (1996), computational estimation of expected times to the most recent common ancestor of samples of n genes under recombination and selection in two-locus, two-allele haploid and diploid models are presented. Such times are conditional on sample configuration. Monte Carlo simulations show that 'hitch-hiking' is a subtle effect that alters the conditional expected depth of the genealogy at the linked neutral locus depending on a mutation-selection-recombination balance.
Genetic Linkage, Applications of graph theory, selection, Haploidy, Problems related to evolution, Animals, Computer Simulation, Selection, Genetic, Monte Carlo inference, random graphs, Alleles, Recombination, Genetic, Models, Genetic, gene genealogies, population genetics, Biological Evolution, Diploidy, recombination, Pedigree, Mutation, Genetics and epigenetics, Monte Carlo Method, Algorithms
Genetic Linkage, Applications of graph theory, selection, Haploidy, Problems related to evolution, Animals, Computer Simulation, Selection, Genetic, Monte Carlo inference, random graphs, Alleles, Recombination, Genetic, Models, Genetic, gene genealogies, population genetics, Biological Evolution, Diploidy, recombination, Pedigree, Mutation, Genetics and epigenetics, Monte Carlo Method, Algorithms
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