The use of robotics in surgical interventions not only has the potential for minimally invasive surgical procedures but can improve performance and result in reduced operative time and post-operative trauma/recovery. This paper describes the concept of a robotic based High Intensity Focused Ultrasound system as a neuro-surgical tool for the destruction of subcortical lesions. A novel multi-transducer applicator system is proposed in order to minimise the effects of off-focal hot-spots and cavitation. Analytical models have been developed for simulating the acoustic field of the multi-transducer system. The models predict the interactive field effects from specific spatial configurations of the probes with respect to each other and to the target. Finally, the design aspects for a robotics based dedicated manipulator for HIFU-based brain surgery have been explored, together with those predicted from a laboratory system.