Abstract In the context of the research on the antecedents of palmar hyperhidrosis, we compared hyperhidrotic in palm and normal individuals on parameters that could be related to excessive sweating. We performed neurological examination, general hematological tests, and measurements of blood levels of thyroid hormones FT3, FT4, TSH, glucose, and electrolytes Na, K, P, Ca, Mg. The participants also filled in the Eysenck Personality, as well as a laboratory constructed Questionnaire. Significantly more hyperhidrotic than normal individuals had a close relative suffering from palmar hyperhidrosis. In addition, hyperhidrotics scored significantly higher in Neuroticism scale of Eysenck Personality Questionnaire. No indi-cation of neurological damage, dysautonomy, hematological abnormality, electrolytic or glucose imbalance, and thyroid gland dysfunction was found for hyperhidrotics. The findings of the present work as well as the ones of previous works suggest that palmar hyperhidrosis cannot be attributed to pathological or anatomical features, it is possibly caused by personality traits, while a genetic predisposition may also contribute.