The H1-histamine antagonist Dithiaden® inhibits human platelets in vitro
Copyright policy )The H1-histamine antagonist Dithiaden® inhibits human platelets in vitro
Cationic amphiphilic drugs (CAD), including antihistaminics, inhibit platelet aggregation in vitro [1]. We demonstrated recently that Dithiaden® (DIT) antagonised stimulated rat platelets at the level of the arachidonic acid pathway suggesting that phospholipase A2 may be the si te of DIT action [2]. The aim of this study was to investigate the effect of the H1-antagonist Dithiaden® on human platelets in vitro and to compare its activity on both animal and human platelets.
- Masaryk University Czech Republic
Blood Platelets, Ionophores, Thrombin, Benzothiepins, Adenosine Diphosphate, Thromboxane B2, Nephelometry and Turbidimetry, Malondialdehyde, Histamine H1 Antagonists, Humans, Calcimycin, Platelet Aggregation Inhibitors
Blood Platelets, Ionophores, Thrombin, Benzothiepins, Adenosine Diphosphate, Thromboxane B2, Nephelometry and Turbidimetry, Malondialdehyde, Histamine H1 Antagonists, Humans, Calcimycin, Platelet Aggregation Inhibitors
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