Information on the role of glucocorticoids in the aging of vertebrate species is reviewed. There is strong evidence that elevated plasma glucocorticoid levels have a causal role in the rapid deterioration following reproduction in semelparous vertebrate species. If this deterioration is an example of rapid senescence, then it is clear that glucocorticoids can promote aging processes in vertebrate species. However, the evidence that glucocorticoids promote aging in the gradual senescence characteristic of most vertebrate species is not robust. Indeed, there is reason to believe that periods of moderately elevated plasma glucocorticoid levels may retard aging processes in rats, mice, and humans.