Sensitivity analysis of pharmacodynamic parameters in pharmacodynamic models

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2001 English Publisher:Springer Science and Business Media LLCJournal:European Journal of Drug Metabolism and Pharmacokinetics, volume 26, pages 59-63 (issn: 0378-7966, eissn: 2107-0180,

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Authors: G, Wu;

doi: 10.1007/bf03190377

pmid: 11554435

Sensitivity analysis of pharmacodynamic parameters in pharmacodynamic models

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Abstract

The quantitative properties of a pharmacodynamic model can be characterized by the pharmacodynamic parameters. The sensitivity analysis of pharmacodynamic parameters in eight kinds of pharmacodynamic models was conducted. The sensitivity functions with respect to different pharmacodynamic parameters for these pharmacodynamic models were deduced using the partial derivative. The pharmacodynamic parameters were ranked according to their sensitivity functions.

Related Organizations

Presses universitaires de la Méditerranée
France
Aix-Marseille University
France
University of the Mediterranean
France

Keywords

Pharmacokinetics, Models, Biological, Algorithms

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