Biotransformation of deprenyl enantiomers

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1999 English Publisher:Springer Science and Business Media LLCJournal:European Journal of Drug Metabolism and Pharmacokinetics, volume 24, pages 315-319 (issn: 0378-7966, eissn: 2107-0180,

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Authors: E, Szökö; H, Kalász; K, Magyar;

doi: 10.1007/bf03190039

pmid: 10892894

Biotransformation of deprenyl enantiomers

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Abstract

Rats were treated with either (-)- or (+)-deprenyl, and the metabolites extracted from the plasma, liver, kidney and heart homogenates were studied by chiral capillary electrophoresis (CE). Stereoselective dealkylation of both optical isomers with the formation of desmethyldeprenyl (DD), methamphetamine (MA), and amphetamine (A) was found. (-)-MA appears to be the main metabolite of (-)-D, and (+)-A for (+)-D. This suggests that the enantiomers undergo a different dealkylation process.

Related Organizations

Semmelweis University
Hungary

Keywords

Male, Monoamine Oxidase Inhibitors, Myocardium, Stereoisomerism, Kidney, Rats, Liver, Selegiline, Animals, Rats, Wistar, Biotransformation

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