Bioavailability of dihydroergosine in healthy volunteers
Copyright policy )Bioavailability of dihydroergosine in healthy volunteers
Eight healthy volunteers received an oral dose of 10 mg and an intravenous dose of 0.75 mg of dihydroergosine. Plasma concentrations were measured by HPLC method, and some pharmacokinetic parameters were calculated. The biologic half-life in the elimination phase was 8.35 +/- 1.87 h after oral administration and 8.84 +/- 3.64 h after intravenous administration. In both cases of administration a secondary rise in plasma concentration of dihydroergosine was observed, which can be attributed to hepatic recycling. The calculated bioavailability of the drug was 9.80 +/- 2.8%.
Adult, Male, Administration, Oral, Biological Availability, Ergotamines, Kinetics, Random Allocation, Injections, Intravenous, Humans, Chromatography, High Pressure Liquid
Adult, Male, Administration, Oral, Biological Availability, Ergotamines, Kinetics, Random Allocation, Injections, Intravenous, Humans, Chromatography, High Pressure Liquid
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!