Excretion of Aflatoxin B1 as a glutathione conjugate

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1981 English Publisher:Springer Science and Business Media LLCJournal:European Journal of Drug Metabolism and Pharmacokinetics, volume 6, pages 265-268 (issn: 0378-7966, eissn: 2107-0180,

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Authors: G O, Emerole;

doi: 10.1007/bf03189524

pmid: 6800796

Excretion of Aflatoxin B1 as a glutathione conjugate

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Abstract

Intraperitoneal injection of 3H - GSH (15.4 mg, 0,5 microCi) 15 minutes before a similar i.p. treatment with Aflatoxin B1 (AFB1) (2mg/kg) showed less than 40% of the radioactivity in the 24 h urine and 30-35% in the bile. Analysis of the urine and bile samples by TLC and separation with XAD-2, showed only traces of the AFB1 - GSH adduct present in the urine and 14% in the bile, AFB1 metabolites isolated from the urine of the 3H - GSH treated rats identical with those of rats treated with AFB1 only. While GSH Conjugate appears therefore to be a major component of biliary excretion of AFB1, it does not seem to be significant in the urinary excretion of the toxin.

Related Organizations

University of Ibadan
Nigeria

Keywords

Male, Aflatoxin B1, Rats, Inbred Strains, Glutathione, Rats, Aflatoxins, Animals, Bile, Chromatography, Thin Layer

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