Deliberate genital self-mutilation is rare. Successful self-castration has been reported in a small number of individuals.This study reports one such case of self-castration in a transsexual who was dissatisfied with waiting times for sex reassignment surgery (SRS).The apparent triggering factor in this case appears to be depression related to the lengthy waiting times for SRS. As neither psychotherapy nor hormonal manipulation is successful, consideration should be given to improving the resources for patients with genuine gender dysmorphism.