Immunological aspects of urate oxidase therapy in hyperuricaemia

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1977 English Publisher:Springer Science and Business Media LLCJournal:Irish Journal of Medical Science, volume 146, pages 155-161 (issn: 0021-1265, eissn: 1863-4362,

Copyright policy )Publicly funded

Authors: D A, Fitzpatrick; O, FitzGerald; K F, McGeeney;

doi: 10.1007/bf03030952

pmid: 608828

Immunological aspects of urate oxidase therapy in hyperuricaemia

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Abstract

The immunological relationship between urate oxidase (uricase) prepared from microbiological and animal sources was studied. The enzymes from these two groups were found to be immunologically unrelated. Within each group cross reaction did occur; cross reactivity was frequent among the enzymes from animal sources. Chemical modification of pork liver enzyme did not alter the immunological integrity of the molecule even when polymerisation of the enzyme was induced.

Related Organizations

University College Dublin
Ireland

Keywords

Urate Oxidase, Animals, Humans, Cross Reactions, Uric Acid

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