Ketamine and pancuronium have been administered intravenously either in rapid sequence or mixed together for the induction of anaesthesia. The subjects were either healthy patients or those suffering from coronary artery disease or mitral stenosis. Changes in blood pressure and pulse rate were variable, a marked tachycardia occurring in some patients. The opinion is expressed that this combination of drugs is potentially dangerous for some patients. Only a careful assessment of each patient in the light of the cardiovascular problem and such other drugs as have been or will be administered, can enable a rational decision to be made regarding the use of this technique for the induction of anaesthesia.