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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Acta Endoscopicaarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Acta Endoscopica
Article . 2006 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Aspects diagnostiques et thérapeutiques des tumeurs stromales digestives

Authors: A. Benkabbou; R. Mohsine; H. O. El Malki; L. Ifrine; A. Belkouchi; R. Afifi; A. Essaid El Feydi; +1 Authors

Aspects diagnostiques et thérapeutiques des tumeurs stromales digestives

Abstract

Les tumeurs stromales (GIST pour gastrointestinal stromal tumors) sont les tumeurs conjonctives les plus frequentes du tube digestif. Elles s’integrent desormais dans un cadre nosologique precis defini par la positivite au CD117 en immunohistochimie. Nous rapportons et analysons une serie de 17 GIST operees a la Clinique chirurgicale « A » (Rabat, Maroc) entre mars 1999 et mars 2005. Nous avons inclus retrospectivement les GIST confirmees a l’examen histologique ayant comporte obligatoirement une etude immunohistochimique. Les donnees demographiques, cliniques, histologiques et therapeutiques des patients ont ete analysees. Nous avons collige 17 cas de GIST, 8 hommes et 9 femmes. L’âge moyen etait de 57 ans (extremes: 20–75 ans). Les localisations tumorales etaient l’estomac (n = 12) et l’intestin grele (n = 3) puis l’œsophage (n = 1) et le rectum (n = 1). Chez 16 patients, le traitement a visee curative a consiste en une resection chirurgicale de premiere intention, adaptee a la localisation tumorale, sans curage ganglionnaire systematique, avec une metastasectomie hepatique dans un cas. La tumeur a ete jugee inextirpable a l’exploration chirurgicale chez une patiente. La resection tumorale a ete realisee par voie cœlioscopique dans un cas. La mortalite operatoire etait nulle. Les suites operatoires immediates etaient simples a l’exception d’une evisceration libre traitee au onzieme jour postoperatoire. Le delai moyen de suivi etait de 9 mois (extremes : 1–40 mois). Huit patients etaient vivants sans recidive. Une patiente ayant developpe, apres 8 mois des metastases hepatiques et peritoneales a ete traitee par imatinib avec une regression des lesions. Un patient en recidive locale (œsophage) est decede apres 17 mois de survie globale. Sept patients ont ete perdus de vue dont un ayant developpe des metastases hepatiques. Le potentiel evolutif de ces tumeurs reste difficile a evaluer, faute de criteres histopronostiques fiables. Le devenir au long cours de nos patients operes pour GIST doit faire l’objet d’une evaluation rapprochee et reguliere en vue d’un depistage precoce des recidives et pour etablir dans un cadre prospectif les facteurs predictifs de recidive. La chirurgie large et complete reste, dans les regions du monde ou l’imatinib ne peut etre distribue, la seule arme therapeutique efficace. Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract, now defined by the immunohistochemical expression of CD117. We report 17 cases of GIST operated between March 1999 and March 2005 in The Clinique chirurgicale « A » of Rabat (Morocco). we have retrospectively included GIST confirmed by histopathological and immunohistochemical examination. Demographic, clinical, pathological and treatment data were analysed. seventeen patients with GIST were operated: 8 men and 9 women. The mean age was 57 years (20–75). Tumours were located in the stomach (n = 12), small intestine (n = 3), oesophagus (n = 1) and rectum (n = 1). Sixteen patients underwent a curative resection adapted to the location, without systematic lymphadenectomy. A patient underwent a hepatic metastasectomy. Resection was not possible in one patient. The mean follow-up was 9 months (1–40). Eight patients were living without recurrence. A patient who had developed liver and peritoneum metastasis was treated by imatinib with good result. A patient operated for oesophagus GIST developed a local recurrence and died 17 months after operation. Seven patients were not followed up, one with liver metastasis. GIST evolution is hard to predict. Close follow-up of our patients would help us to identify and treat recurrence earlier and determine local patterns of tumour recurrence. Complete and wide surgical resection remains the only efficient treatment in regions where imatinib is not available.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
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