Transglutaminase in cell proliferation and transformation
Copyright policy )Transglutaminase in cell proliferation and transformation
Transglutaminase (TGase) activity was reduced in intact mitogen-stimulated human peripheral blood lymphocytes (PBL) when compared to intact resting PBL. Moreover, a treatment of the same quiescent immunocompetent cells with purified liver TGase and Ca2+ completely suppressed the mitogen-induced blast transformation. A decrease in TGase activity in neoplastically transformed seminal vesicle epithelial cells with respect to their normal parent counterpart was also observed. Our data support the notion of a possible implication of TGase in cell proliferation and transformation.
- University of Campania "Luigi Vanvitelli" Italy
- University Federico II of Naples Italy
- Institute of Protein Biochemistry Italy
- National Research Council Italy
- ARCO United States
Transglutaminases, Proteins, Rats, Inbred Strains, Binding, Competitive, Catalysis, Cell Line, Culture Media, Rats, Cell Transformation, Neoplastic, Liver, Concanavalin A, Tumor Cells, Cultured, Animals, Calcium, Harvey murine sarcoma virus, Lymphocytes, Mitogens, Kirsten murine sarcoma virus, Cell Division
Transglutaminases, Proteins, Rats, Inbred Strains, Binding, Competitive, Catalysis, Cell Line, Culture Media, Rats, Cell Transformation, Neoplastic, Liver, Concanavalin A, Tumor Cells, Cultured, Animals, Calcium, Harvey murine sarcoma virus, Lymphocytes, Mitogens, Kirsten murine sarcoma virus, Cell Division
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