Genetic aspects of multidrug resistance

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Mar 1992 English Publisher:Springer Science and Business Media LLCJournal:Medical Oncology and Tumor Pharmacotherapy, volume 9 (issn: 0736-0118,

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Authors: M, Pauly; F, Ries; M, Dicato;

doi: 10.1007/bf02989649

pmid: 1364127

Genetic aspects of multidrug resistance

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Abstract

Gene amplification is responsible both for dihydrofolate reductase induced methotrexate resistance, and for the P-glycoprotein encoding multigene family induced multidrug resistance. The 6 pairs of hydrophobic regions of the P-glycoprotein fold up in a snake-like structure through the lipidic layers of the cell membrane. Other detoxification mechanisms include the glutathione S-transferase 'pi', but without gene amplification.

Related Organizations

Centre Hospitalier de Luxembourg
Luxembourg

Keywords

Membrane Glycoproteins, Drug Resistance, Gene Amplification, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Neoplasms, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Carrier Proteins

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