Abnormal regulation of the myc gene in myeloid leukemia
Copyright policy )Abnormal regulation of the myc gene in myeloid leukemia
To study the regulation of expression of the myc protooncogene, cells from normal individuals and patients with acute myelogenous leukemia (AML), and chronic phase and blastic crisis of chronic myeloid leukemia (CML) cells were put in overnight culture in the presence or absence of fetal calf serum. Myc expression in normal marrow cells and chronic phase CML cells fell after culture in vitro. In contrast, myc expression was maintained or increased in a majority of the AML and blastic crisis CML specimens. These data demonstrate that the regulation of myc expression is disordered in many AML and blastic crisis specimens but not in chronic phase CML cells.
- University System of Ohio United States
- University of Cincinnati United States
- University of Cincinnati Medical Center United States
Base Sequence, Gene Expression Regulation, Leukemic, Molecular Sequence Data, Genes, myc, Interferon-alpha, Bone Marrow Cells, Cell Count, Tretinoin, Interferon alpha-2, Recombinant Proteins, Blotting, Southern, Leukemia, Myeloid, Acute, Genes, ras, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mutation, Tumor Cells, Cultured, Humans, RNA, Neoplasm, Blast Crisis
Base Sequence, Gene Expression Regulation, Leukemic, Molecular Sequence Data, Genes, myc, Interferon-alpha, Bone Marrow Cells, Cell Count, Tretinoin, Interferon alpha-2, Recombinant Proteins, Blotting, Southern, Leukemia, Myeloid, Acute, Genes, ras, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mutation, Tumor Cells, Cultured, Humans, RNA, Neoplasm, Blast Crisis
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).11 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!