Negative Regulators of Cytokine Signaling
Copyright policy )Negative Regulators of Cytokine Signaling
The interaction of a cytokine with its specific cell surface receptor triggers the activation of intracellular signaling pathways that ultimately program the cellular response. Although the specific components and actions of the pathways driving these responses, such as the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway, are relatively well defined, it is becoming clear that important mechanisms exist to restrain these signaling cascades. This review discusses the key biochemical actions and biological roles of the phosphatase SHP-1, the protein inhibitors of activated STATs (PIAS) and the suppressor of cytokine signaling (SOCS) protein family in the negative regulation of cytokine signal transduction.
- Melbourne Health Australia
- Royal Melbourne Hospital Australia
- Walter and Eliza Hall Institute of Medical Research Australia
Mice, Knockout, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Intracellular Signaling Peptides and Proteins, Mice, Transgenic, Protein-Tyrosine Kinases, Models, Biological, Protein Inhibitors of Activated STAT, DNA-Binding Proteins, Enzyme Activation, Mice, Gene Expression Regulation, Gene Targeting, Animals, Cytokines, Humans, Phosphorylation, Protein Tyrosine Phosphatases, Carrier Proteins, Dimerization, Protein Processing, Post-Translational
Mice, Knockout, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Intracellular Signaling Peptides and Proteins, Mice, Transgenic, Protein-Tyrosine Kinases, Models, Biological, Protein Inhibitors of Activated STAT, DNA-Binding Proteins, Enzyme Activation, Mice, Gene Expression Regulation, Gene Targeting, Animals, Cytokines, Humans, Phosphorylation, Protein Tyrosine Phosphatases, Carrier Proteins, Dimerization, Protein Processing, Post-Translational
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