The thermolability of tissue thromboplastins
Copyright policy )The thermolability of tissue thromboplastins
1. The thermolability of tissue thromboplastins is markedly increased in the presence of cysteine, glutathione sulphite and hydrosulphite, but not in the presence of cysteine, ascorbate, thiosulphate or thiocyanate. 2. Thermostability is increased by fluoride (and ageing), but is overcome by cysteine. 3. These effects were demonstrated with tissue thromboplastins from brain, chorion and a thyroid carcinoma, and were found equally with conventional water-soluble and lipoid-type substances. 4. Thermolability appears to be dependent upon the presence of free thiols or their equivalent in an enzyme catalysed reaction.
- Trinity College Dublin Ireland
Brain Chemistry, Hot Temperature, Animals, Humans, Rabbits, In Vitro Techniques, Thromboplastin
Brain Chemistry, Hot Temperature, Animals, Humans, Rabbits, In Vitro Techniques, Thromboplastin
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