Cytotoxic constituents from Angelicae Sinensis radix
Copyright policy )Cytotoxic constituents from Angelicae Sinensis radix
Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimeric Z-ligustilide, named neodiligustilide (1), together with three known compounds, Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z, 17-dien-12,14-diyn-1-yl acetate (3), and 3(R),8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 +/- 0.10 and 4.78 +/- 0.18 microM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 +/- 0.19 and 9.87 +/- 0.14 microM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 +/- 0.90 and 2.87 +/- 0.49 microM, respectively.
- Kyungpook National University Korea (Republic of)
- Chonnam National University Korea (Republic of)
- Chungbuk National University Korea (Republic of)
- Korea Research Institute of Bioscience and Biotechnology Korea (Republic of)
- United States Food and Drug Administration United States
Mice, Angelica sinensis, Animals, Humans, K562 Cells, Leukemia L1210, Antineoplastic Agents, Phytogenic
Mice, Angelica sinensis, Animals, Humans, K562 Cells, Leukemia L1210, Antineoplastic Agents, Phytogenic
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