Cytotoxic ergosterols frompaecilomyces sp. J300
Copyright policy )Cytotoxic ergosterols frompaecilomyces sp. J300
Seven ergosterol derivatives (1-7) were isolated from silkworm larvae infected with Paecilomyces sp. J300. On the basis of spectroscopic means, their structures have been elucidated as 3beta,5alpha-dihydroxy-ergosta-7,22-diene (1), 5alpha,6alpha-epoxy-(22E,24R)-ergosta-8(14), 22-diene-3beta, 7alpha-diol (2), 5alpha,6alpha-epoxy-(22E,24R)-ergosta-8,22-diene-3beta,7alpha-diol (3), ergosta-4,6,8(14),22-tetraene-3-one (4), ergosterol (5), ergosterol endoperoxide (6), 3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene (7). Compounds 3-7 showed moderate cytotoxicity against five tumor cells.
- Sungkyul University Korea (Republic of)
- Sungkyunkwan University Korea (Republic of)
- KORA Organics Australia
- National Institute of Agricultural Science and Technology Korea (Republic of)
Ergosterol, Tumor Cells, Cultured, Animals, Humans, Drug Screening Assays, Antitumor, Bombyx, Paecilomyces
Ergosterol, Tumor Cells, Cultured, Animals, Humans, Drug Screening Assays, Antitumor, Bombyx, Paecilomyces
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