Synthesis and immunosuppressive activity of novel succinylacetone analogues

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2003 English Publisher:Springer Science and Business Media LLCJournal:Archives of Pharmacal Research, volume 26, pages 192-196 (issn: 0253-6269, eissn: 1976-3786,

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Authors: Taek Hyeon, Kim; Dong Ryun, Oh; Hee Sam, Na; Hyun Chul, Lee;

doi: 10.1007/bf02976828

pmid: 12723930

Synthesis and immunosuppressive activity of novel succinylacetone analogues

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Abstract

This study describes the synthesis of novel enol esters (3) and triketones (4) as analogues of succinylacetone (SA) (Ed- this abbreviation is introduced here based on your use of it in the body of the paper) and the evaluation on the mouse allogeneic mixed lymphocyte reaction (MLR) and the murine model of antigen-induced paw edema formation for immunosuppressive activity. Enol esters (3a-f) were about 2-4 fold more potent than SA in in vitro activity.

Related Organizations

Chonnam National University
Korea (Republic of)

Keywords

Mice, Inbred C57BL, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Animals, Edema, Immunosuppressive Agents, Spleen, Heptanoates

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