Pheophorbide a-methyl ester, acyl-coa: cholesterol acyltransferase inhibitor fromDiospyros kaki

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2003 English Publisher:Springer Science and Business Media LLCJournal:Archives of Pharmacal Research, volume 26, pages 716-718 (issn: 0253-6269, eissn: 1976-3786,

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Authors: Mun-Chual, Rho; Mi Yeon, Chung; Hye Young, Song; Oh Eok, Kwon; Seung Woong, Lee; Jin Ah, Baek; Kyung Hee, Jeune; +3 Authors

doi: 10.1007/bf02976679

pmid: 14560918

Pheophorbide a-methyl ester, acyl-coa: cholesterol acyltransferase inhibitor fromDiospyros kaki

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Abstract

In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 microg/mL.

Related Organizations

Korea Research Institute of Bioscience and Biotechnology
Korea (Republic of)
Yeungnam University
Korea (Republic of)

Keywords

Chlorophyll, Methyl Ethers, Korea, Dose-Response Relationship, Drug, Molecular Structure, Plant Extracts, Methanol, Diospyros, Gas Chromatography-Mass Spectrometry, Rats, Plant Leaves, Microsomes, Liver, Animals, Acyl Coenzyme A, Chromatography, High Pressure Liquid, Drugs, Chinese Herbal, Sterol O-Acyltransferase

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