Synthesis and analgesic and anti-inflammatory activities of 1,2-benzothiazine derivatives
Copyright policy )Synthesis and analgesic and anti-inflammatory activities of 1,2-benzothiazine derivatives
Three 1,2-benzothiazine derivatives were synthesized, and their analgesic/anti-inflammatory efficacy and their effects on gastric irritation were evaluated. Among the three compounds, 39 exhibited the most potent analgesic action, but the effect was weaker than that of piroxicam. Nonetheless, the compound showed 4 times more potent analgesic action with less gastric damage than did ibuprofen. These compounds did not show anti-inflammatory effect at an oral dose of 5 mg/kg.
- Seoul National University Korea (Republic of)
- Duksung Women's University Korea (Republic of)
Male, Mice, Inbred ICR, Anti-Inflammatory Agents, Non-Steroidal, Thiazines, Analgesics, Non-Narcotic, Carrageenan, Rats, Mice, Gastric Mucosa, Animals, Edema
Male, Mice, Inbred ICR, Anti-Inflammatory Agents, Non-Steroidal, Thiazines, Analgesics, Non-Narcotic, Carrageenan, Rats, Mice, Gastric Mucosa, Animals, Edema
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).8 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!