
doi: 10.1007/bf02975134
pmid: 15742807
Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.
Carcinoma, Hepatocellular, Dose-Response Relationship, Drug, Liver, Nitrofurantoin, Plant Extracts, Cell Line, Tumor, Plant Bark, Humans, Moraceae, Plant Roots
Carcinoma, Hepatocellular, Dose-Response Relationship, Drug, Liver, Nitrofurantoin, Plant Extracts, Cell Line, Tumor, Plant Bark, Humans, Moraceae, Plant Roots
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