Phytochemical constituents ofArtemisia stolonifera

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2001 English Publisher:Springer Science and Business Media LLCJournal:Archives of Pharmacal Research, volume 24, pages 312-315 (issn: 0253-6269, eissn: 1976-3786,

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Authors: H C, Kwon; S U, Choi; K R, Lee;

doi: 10.1007/bf02975098

pmid: 11534763

Phytochemical constituents ofArtemisia stolonifera

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Abstract

Repeated column chromatographic separation of the CH2Cl2 extract of Artemisia stolonifera (Asteraceae) led to the isolation of a triterpene (I), a sesquiterpene (II), two aromatic compounds (III and IV) and a benzoquinone (V). Their structures were determined by spectroscopic means to be simiarenol (I), (1S,7S)-1beta-hydroxygermacra-4(15),5,10(14)-triene (II), 3'-methoxy-4'-hydroxy-trans-cinnamaldehyde (III), vanillin (IV) and 2,6-dimethoxy-1,4-benzoquinone (V), respectively. Among these products, compound V showed significant cytotoxicity against five human tumor cell lines in vitro, A549 (non small cell lung adenocarcinoma), SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), XF498 (CNS) and HCT15 (colon) with ED50 values ranging from 1.33-4.22 microg/ml.

Related Organizations

Sungkyul University
Korea (Republic of)
Sungkyunkwan University
Korea (Republic of)
Korea Research Institute of Chemical Technology
Korea (Republic of)

Keywords

Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Artemisia, Spectrophotometry, Infrared, Tumor Cells, Cultured, Humans, Drug Screening Assays, Antitumor, Antineoplastic Agents, Phytogenic

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