Six patients with insulin-dependent diabetes mellitus were treated by continuous subcutaneous insulin infusion for a period of 24–64 weeks. Diabetic control improved, indicated by a fall in the mean preprandial blood glucose and haemoglobin A1 levels. Renal function was unaltered in one patient with diabetic nephropathy but background retinopathy deteriorated in another. However, all patients reported an improved sense of well-being and expressed a reluctance to revert to conventional twice daily insulin despite the inconvenience of wearing the device and need for frequent blood glucose monitoring. Continuous subcutaneous insulin infusion is an acceptable means of managing insulin-dependent diabetes. *** DIRECT SUPPORT *** A00IA373 00004