Apoptosis inducing effect of meisoindigo on K562 cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1999 English Publisher:Springer Science and Business Media LLCJournal:Chinese Journal of Integrated Traditional and Western Medicine, volume 5, pages 220-220 (issn: 1006-6497,

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Authors: L, Song; L, Qian;

doi: 10.1007/bf02935182 , 10.1007/bf02970594

pmid: 11783201

Apoptosis inducing effect of meisoindigo on K562 cells

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Abstract

To study the effect of meisoindigo on human chronic myelogenous leukemia (CML) cell line K562 cells for exploring the mechanism of meisoindigo in treatment of CML.Multiple methods, including dose-response curve, trypan blue exclusion, cytomorphology, DNA electrophoresis, flow cytometry and TUNEL (TdT mediated dUTP nick and labeling), were used to observe the effect of meisoindigo on K562 cells.Meisoindigo can inhibit the proliferation and induce the apoptosis of K562 cells.The therapeutic mechanism of meisoindigo in treating CML may be related with its proliferation inhibiting and apoptosis inducing effect in CML cells.

Related Organizations

PEKING UNION MEDICAL COLLEGE
China (People's Republic of)
Chinese Academy of Medical Sciences & Peking Union Medical College
China (People's Republic of)
Institute of Hematology & Blood Diseases Hospital
China (People's Republic of)

Keywords

Indoles, Humans, Apoptosis, K562 Cells, Cell Division

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