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Generating human monoclonal antibodies

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jun 1984 English Publisher:Springer Science and Business Media LLCJournal:Medical Oncology and Tumor Pharmacotherapy, volume 1, pages 73-76 (issn: 0736-0118,

Authors: P. A. W. Edwards; M. J. O'Hare; A. M. Neville;

doi: 10.1007/bf02934977

pmid: 6100557

Generating human monoclonal antibodies

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Abstract

Present methods and systems for the generation of human monoclonal antibodies are briefly reviewed. The specificities of the available reagents are outlined. It would appear that the generation using hybridoma methods of human monoclonal antibodies to human tumor cell surface antigens is a rare event and that methods of in vitro immunostimulation may have to be used if such antibodies are to be reliably produced.

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Keywords

Herpesvirus 4, Human, Mice, Hybridomas, Animals, Antibodies, Monoclonal, Humans, Cell Transformation, Viral

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