Sixty-eight cases of Non-Insulin Dependent Diabetes Mellitus complicated with Nephropathy were randomly divided into two groups: the treated group, 35 cases treated with alcohol extraction of Flos A-belmoschus manihot, Gliclazide and Captopril Tablets; and the control group, 33 cases treated with Gliclazide and Captopril Tablets, over a period of 8 weeks. The total effective rate in the treated and control group were 83.87% and 31.03% respectively (P<0.01), urinary micro-albumin were 31.7 and 76.3mg/L (P<0.05), proteinuria were 0.41 and 0.77g/24hr (P<0.01), blood β-microglobulin were 3317.8 and 3473. 1 hg/ml (P<0.05), urinary β-microglobulin were 367.2 and 641.5ng/ml (P<0.01), urinary N-acetyl-β-glucosaminidase (NAG) were 26.3 and 66. 7u/L (P<0.01), plasma lipid peroxide (LPO) were 6.13 and 8.78 nmol/L (P<0. 05), and plasma superoxide anion were 8.36 and 10.42 kcpm respectively (P<0.05). It was suggested that alcohol extraction ofAbelmoschus manihot could eliminate oxygen free radicals, alleviate renal tubular-interstitial diseases, improve renal function, and reduce proteinuria.