Biotransformation of withaferin-a by a culture ofArthrobacter simplex

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1985 English Publisher:Springer Science and Business Media LLCJournal:Folia Microbiologica, volume 30, pages 427-432 (issn: 0015-5632, eissn: 1874-9356,

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Authors: J. Funska; A. Khandlová; M. Šturdíková; J. P. Rosazza; K. Kieslich;

doi: 10.1007/bf02928752

Biotransformation of withaferin-a by a culture ofArthrobacter simplex

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Abstract

Arthrobacter simplex biotransformed withaferin-A under submerged conditions to 7 new derivatives while 4,27-di-O-acetylwithaferin-A was transformed to another 9 derivatives. The melting point of all these substances was determined, along with RF values and colour reactions with 4-anisaldehyde reagent. Derivatives also differed in their biological effects on P388 cells. A marked inhibitory effect on the synthesis of nucleic acids and proteins in the leukemia cells P388 was found in 12 out of 16 new derivatives.

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