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Inhibition of DNA restriction enzyme digestion by anthracyclines

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1988 Italy Publisher:Springer Science and Business Media LLCJournal:La Ricerca in Clinica e in Laboratorio, volume 18, pages 19-22 (issn: 0390-5748,

Authors: G. Corneo; E. Pogliani; D. Biassoni; P. Tripputi;

doi: 10.1007/bf02918815

pmid: 2836942

handle: 2434/209658

Inhibition of DNA restriction enzyme digestion by anthracyclines

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Abstract

The inhibition of restriction enzyme digestion of lambda phage DNA by anthracyclines (i.e., adriamycin, daunomycin, epirubicin, idarubicin and esorubicin) commonly used in the treatment of human leukemia and cancer has been studied in vitro. The anthracyclines used inhibit DNA digestion by SmaI, AvaII, HaeIII, HhaI and HpaII, which cut DNA at guanine-cytosine (G-C) sequence sites, and by EcoRI, which cut DNA at adenine adenine-thymine thymine (AATT) sequence sites. Adriamycin completely inhibits DNA restriction by the indicated enzymes, daunomycin, epirubicin and idarubicin determine only a partial inhibition, while esorubicin does not inhibit DNA restriction at all. An attempt is made to correlate the extent of the in vitro interaction between anthracyclines and DNA to in vivo cardiotoxicity.

Country

Italy

Related Organizations

University of Milan
Italy

Keywords

Antibiotics, Antineoplastic, Naphthacenes, DNA, Viral, Anthracyclines; Cancer; Deoxyribonucleic acid (DNA); Leukemia; Restriction enzymes, DNA Restriction Enzymes, Bacteriophage lambda

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