Lifespan of lymphocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1995 English Publisher:Springer Science and Business Media LLCJournal:Immunologic Research, volume 14, pages 1-12 (issn: 0257-277X, eissn: 1559-0755,

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Authors: D F, Tough; J, Sprent;

doi: 10.1007/bf02918494

pmid: 7561338

Lifespan of lymphocytes

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Abstract

T and B lymphocytes comprise heterogeneous populations of cells at various stages of differentiation and activation. T- and B-cell subsets have different roles in the maintenance of immune homeostasis, and their functional differences are reflected by their respective lifespans. This review briefly summarizes the available data on lymphocyte lifespan, including the kinetics of T- and B-cell development in the primary lymphoid organs and the proliferative behavior of naive, effector and memory lymphocytes in the peripheral lymphoid compartment.

Related Organizations

Scripps Research Institute
United States

Keywords

B-Lymphocytes, Lymphoid Tissue, T-Lymphocytes, Animals, Humans, Cell Differentiation, Lymphocytes, Lymphocyte Activation, Immunologic Memory, Cellular Senescence

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