Compared to the lower airways the human nose offers an extremely accessible part of the human airways. In recent years, several methods have been devised allowing us to study different components in reactions that occur in the upper airways. By choosing the right methods for the right questions, we will be able to obtain valuable information on the pathophysiology and pharmacology of nasal disorders. This information might not only be relevant to the upper airway; it may well be applicable to other parts of the airways as well.