Cytoplasmic immunoglobulins in giant lymph node hyperplasia (Castleman’s tumour)

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1981 English Publisher:Springer Science and Business Media LLCJournal:Virchows Archiv B Cell Pathology Including Molecular Pathology, volume 38, pages 239-246 (issn: 0042-6431,

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Authors: W T, Dura; O, Mioduszewska; A, Porwit-Ksiazek;

doi: 10.1007/bf02892818

pmid: 6119848

Cytoplasmic immunoglobulins in giant lymph node hyperplasia (Castleman’s tumour)

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Abstract

The immunohistologic features were studied in 6 cases of giant lymph node hyperplasia (GLNH) and the cytoplasmic immunoglobulin (CIg) characteristics were compared with those of follicular lymphoma and non-specific follicular lymph node hyperplasia. By use of the peroxidase - antiperoxidase (PAP) technique it was shown that GLNH comprised a mosaic, polyclonal population of CIG-producing cells, the CIg pattern being comparable with that observed in follicular lymphadenitis. In contrast, follicular lymphomas disclosed a definite monoclonal pattern, the cytoplasmic Ig containing only one light chain of kappa type. This led to the conclusion that GLNH is not a neoplastic change, but has the characteristics of a reactive process within the B-cell compartment.

Keywords

B-Lymphocytes, Hyperplasia, Immunoglobulins, Immunoglobulin D, Immunoglobulin A, Immunoglobulin M, Lymphadenitis, Immunoglobulin G, Humans, Lymph Nodes, Lymphatic Diseases

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