Microbiological and chemical dehydrogenation of withaferin A

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1987 English Publisher:Springer Science and Business Media LLCJournal:Folia Microbiologica, volume 32, pages 112-115 (issn: 0015-5632, eissn: 1874-9356,

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Authors: J, Fuska; B, Proska; J, Williamson; J P, Rosazza;

doi: 10.1007/bf02883237

pmid: 3583136

Microbiological and chemical dehydrogenation of withaferin A

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Abstract

Arthrobacter simplex dehydrogenated withaferin A to 4-dehydrowithaferin A but it was not able to dehydrogenate this substrate in position 27. 27-Dehydrowithaferin A was prepared chemically using pyridinium chlorochromate. Whereas 4-dehydrowithaferin A surpassed in its effect on leukemic (388 cells the original compound and all its derivates synthesized so far, 27-dehydrowithaferin A was biologically inactive.

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Keywords

Chemistry, Leukemia, Experimental, Chemical Phenomena, Cell Survival, Leukemia P388, Ergosterol, Animals, Arthrobacter, Withanolides, Cell Line

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