I. Compatible method, a new mode of control, is advocated in helping to guide diabetic therapy because: (a)53% of our group of 100 patients discontinued insulin for an average period, which has existed for 2 years and 8 months. This latter period for the individual patient varied from 2 months to 9 years and 6 months. (b)There was a greater incidence of weight gain (30 patients had an average gain of 9 lbs.) during the diet period (interval in which insulin was discontinned) than during the initial insulin therapy period (17 patients with an average gain of 4.4 lbs.) in the 53 patients. In the 47 patients who were on or off insulin therapy there was no significant comparable change in the weight loss and gain. (c)It combines the clinical and the laboratory methods to help stabilize the diabetes. II. Clinical evidence of arteriovascular degeneration in the various groups did not appear to be related to the level of the blood sugar, insulin therapy, or apparent duration of the diabetes.