Expression of pin1 and ki67 in cervical cancer and their significance

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2006 English Publisher:Springer Science and Business Media LLCJournal:Journal of Huazhong University of Science and Technology [Medical Sciences], volume 26, pages 120-122 (issn: 1672-0733, eissn: 1993-1352,

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Authors: Hongyu, Li; Hongling, Shen; Qian, Xu; Dongrui, Deng; Shixuan, Wang; Yunping, Lu; Ding, Ma;

doi: 10.1007/bf02828056

pmid: 16711024

Expression of pin1 and ki67 in cervical cancer and their significance

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Abstract

In order to investigate the expression levels of Pin1 mRNA and protein in cervical cancer and its association with Ki67 and their clinical significance, amplification of Pin1 gene was examined by RT-PCR, and the expression of both Pin1 and Ki67 protein was detected by immunohistochemistry in cervical cancer tissues. It was shown that the expression levels of Pin1 were higher in cervical cancer than in normal cervical tissues (P 0.05). The expression of Pin1 was significantly higher in adenocarcinoma than in squamous carcinoma of the uterine cervix (P < 0.05). In cervical cancer, the overexpression of Pin1 was positively correlated with that of Ki67 (P < 0.05). These results suggested that the overexpression of Pin1 was closely related with cancer cell proliferation or progression of cervical cancer and contributed to oncogenesis. Pin1 may serve as a potential marker for cervical cancer diagnosis.

Related Organizations

Third Affiliated Hospital of Nanchang University
China (People's Republic of)
Tongji Hospital
China (People's Republic of)
Zhengzhou University
China (People's Republic of)
Huazhong University of Science and Technology
China (People's Republic of)

Keywords

NIMA-Interacting Peptidylprolyl Isomerase, Ki-67 Antigen, Biomarkers, Tumor, Humans, Uterine Cervical Neoplasms, Female, Peptidylprolyl Isomerase, Uterine Cervical Dysplasia

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