Neurotoxicity of immunotoxins

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1994 English Publisher:Springer Science and Business Media LLCJournal:Molecular and chemical neuropathology, volume 21, pages 379-386 (issn: 1044-7393,

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Authors: O, Ilercil; D W, Laske; S, Walbridge; K, Muaszko; E H, Oldfield; R J, Youle;

doi: 10.1007/bf02815363

pmid: 8086044

Neurotoxicity of immunotoxins

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Abstract

Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecular basis for the unexpected neural involvement and to prevent or minimize this toxicity in future clinical trials.

Related Organizations

National Institutes of Health
United States
National Institute of Neurological Disorders and Stroke
United States

Keywords

Central Nervous System, Clinical Trials as Topic, Brain Neoplasms, Immunotoxins, Neoplasms, Tumor Cells, Cultured, Animals, Humans, Female

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